Week 3: Control of Ventilation, Ventilation-Perfusion Matching, Cardiovascular Responses

This week covers the neural and chemical control of ventilation, ventilation-perfusion matching in the lung, and the cardiovascular responses that deliver oxygen to working muscles.

Lectures

• Lecture 7: Control of Ventilation and Ventilation-Perfusion Matching (27 slides) Brainstem control of ventilation, chemoreceptor responses to CO₂ and O₂, the Fick principle, ventilation-perfusion ratio (V/Q), shunts, dead space, and V/Q heterogeneity across species.

• Lecture 8: Cardiovascular Responses to Exercise (39 slides) The Fick principle for O₂ delivery, heart rate and stroke volume, Frank-Starling mechanism, blood pressure, blood flow redistribution, oxygen-hemoglobin dissociation and the Bohr effect, cardiovascular drift.

• Week 3 Friday Review and Discussion (20 slides) V/Q matching, the oxygen-hemoglobin dissociation curve and Bohr effect, myoglobin, the graphical Fick principle, and a practice problem on cardiac output and stroke volume.